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Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum.

Hou Y, Yang JY, Wu CF, Huang M

Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.R. China.

The effects of clozapine, olanzapine and haloperidol on ethanol-induced striatal ascorbic acid (AA) release in mice were compared by using microdialysis coupled to high performance liquid chromatography with electrochemical detection. Ethanol (4.0 g/kg i.p.) significantly stimulated striatal AA release by about 200% of baseline in mice. Clozapine and olanzapine, two atypical neuroleptic drugs, at the dose of 1.0 mg/kg s.c., had no effect on basal AA or ethanol-induced AA release. However, both drugs, at the dose of 10 mg/kg s.c., significantly inhibited ethanol-induced AA release. In contrast, haloperidol, a typical neuroleptic drug, at the doses of 0.1-2.0 mg/kg, had no effect on both basal and ethanol-induced AA release. The present study demonstrated that similar actions were exhibited by clozapine and olanzapine, but not by haloperidol, for the regulation of ethanol-induced AA release in the mouse striatum.

Published 21 December 2004 in Prog Neuropsychopharmacol Biol Psychiatry, 29(1): 83-9.
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