Vitamin C Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin C, including details on benefits, dosage, supplements, information.

Serum oxidant/antioxidant balance in exfoliation syndrome.

Yimaz A, Adigüzel U, Tamer L, Yildirim O, Oz O, Vatansever H, Ercan B, Değirmenci US, Atik U

Department of Ophthalmology, Mersin University Faculty of Medicine, Mersin, Turkey.

BACKGROUND: To evaluate the relationship between the serum oxidant-antioxidant balance and the presence of exfoliation syndrome (XFS) in a prospective study. METHODS: The study group comprised 27 cases of XFS. Serum concentrations of myeloperoxidase, malondialdehyde, vitamins A, C and E, catalase and total antioxidant were measured and compared with an independent group by t-test. RESULTS: Serum myeloperoxidase, vitamins A and E, catalase and total antioxidant parameters were not statistically different among the groups (P >0.05). Serum vitamin C concentrations were significantly lower and malondialdehyde concentrations were significantly higher in cases of XFS when compared with the control group (P=0.008 and P=0.002, respectively). CONCLUSION: An altered oxidant-antioxidant balance may play a role in the pathogenesis of XFS.

Published 26 January 2005 in Clin Experiment Ophthalmol, 33(1): 63-6.
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